Raychel Ferguson was nine when she died at the Royal Belfast Hospital for Sick Children in 2001.
The closure of Mullaghbawn practice will leave more than 5,000 patients without a registered doctor.
The government says vaping has become a huge epidemic, particularly affecting young people.
A meeting later is likely to see a deal in England agreed but nurses are still threatening strikes.
Hospitals that refused life-saving care during an emergency broke federal rules, health officials say.
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